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About Regional Cancer Therapies

Regional cancer therapy refers to the delivery of targeted treatments such as chemotherapy or radiation to a specific organ or compartment, sparing the rest of the body from potential toxicities. Traditional treatments can put normal tissues remote from the region being treated at risk. For example, systemic chemotherapy exposes the entire body to side effects, while chemotherapy delivered directly to the organ being treated minimizes damage surrounding tissues. These treatment decisions are complex and requires the coordinated effort of all parts of a comprehensive, expert, multidisciplinary cancer team.

Program Description

The Northwestern Medicine and Lurie Cancer Center Regional Therapeutics Program will focus on the comprehensive management of patients with advanced malignancies amenable to regional therapy options. Patients will be evaluated by our expert multidisciplinary team and a consensus recommendation tailored to each individual patient will be provided.

The NM and Lurie Cancer Center Regional Therapeutics Program offers:

  • Comprehensive, multidisciplinary, cutting edge, compassionate and patient-centered cancer care consistent with the core values of Northwestern Medicine and the Robert H. Lurie Comprehensive Cancer Center
  • A world class Regional Therapeutics Program that spans diseases, disciplines and specialties
  • Access to the latest trials, protocols and next generation treatment options.

The NM and Lurie Cancer Center Regional Therapeutics Program includes treatment for the following cancers:


Our experts at Northwestern Medicine offer the following procedures:

  • Intraperitoneal chemotherapy
    • Hyperthermic intraperitoneal chemotherapy (HIPEC) [circulation of heated chemotherapy in the abdominal cavity after removing all visible disease]
    • Early postoperative chemotherapy (EPIC) [circulation of chemotherapy after surgery through a port that is placed into the abdominal cavity]
  • Intrathoracic chemotherapy
    • Hyperthermic intrathoracic chemotherapy (HITEC) [circulation of heated chemotherapy in the chest cavity after removing all visible disease]
  • Liver-directed therapies
    • Hepatic artery infusion chemotherapy [administration of chemotherapy directly into the liver using a pump that is placed under the skin]
    • Chemoembolization [administration of targeted chemotherapy combined with obstructing the blood flow to tumors in the liver]
    • Radioembolization (e.g., yttrium-90) [administration of targeted radiation combined with obstructing the blood flow to tumors in the liver]
    • Thermal ablation (percutaneous and/or operative approaches including minimally invasive surgical techniques) [using advanced technology to selectively destroy tumors in the liver using heat or freezing techniques]
    • External beam radiation therapy [using radiation to selectively target tumors]
  • Isolated limb infusion [applying heated chemotherapy selectively to a limb to treat skin cancer]
  • Intravesicular chemotherapy [administration of chemotherapy to the inside of the bladder to selectively target bladder tumors]
  • Talimogene Laherparepvec (T-VEC) [skin injection that stimulates the immune system to treat metastatic melanoma]