Overview

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune inflammatory disorder. It affects your central nervous system (CNS). The CNS is responsible for processing everything you do, from your thoughts to your movements and breathing.

MOGAD occurs when your immune system attacks the protective layer (myelin) around the fibers in your brain, spinal cord and optic nerves. The attack can cause swelling (inflammation) that blocks or slows nerve signals from your brain. This means your brain cannot tell parts of your body what to do.

Some people experience more than one attack. This is called relapsing MOGAD. Others may have just one attack (monophasic MOGAD).

Attacks can cause long-term damage to your CNS. This can affect your ability to see, move, use the bathroom and think.

MOGAD is rare, and it can affect children and adults.