Daniel J. Sepe, MD | Northwestern Medicine

Practice Focus Areas

This medical professional has a particular interest or expertise in:

Acute and Preventive Care
Adult Medicine
Cholesterol Management
Comprehensive Primary Care
Men's Health
Preventive Medicine
Weight Management
Well Women Care

Education

Medical Education:: MD, St Louis University School of Medicine - 2020
Residency:: Prime Midwest GME Consortium - 2023

Board Certifications

American Board of Family Medicine - Family Medicine (Certified)

Faculty Profile

Clinical Assistant Professor, Feinberg School of Medicine

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Practice Groups and Affiliations

Medical Group:: Northwestern Medical Group
Alignment Category:: Northwestern Medicine Physician Network
On Medical Staff At:: Northwestern Memorial Hospital

Ratings and Reviews

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Overall Rating

4.9

4.9

781 Ratings

Reviews from Patients

100 Most Recent Reviews

Reviews from Patients

100 Most Recent Reviews

February 27, 2026

5.0

He described thoroughly and encouraged more physical activity

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February 26, 2026

5.0

He listens and provides information.

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February 26, 2026

5.0

Efficient, thorough, expert, good people skills.

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February 25, 2026

5.0

Professional, friendly, knowledgeable and efficient care.

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February 24, 2026

5.0

Doctor that shows he cares , listens to you

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February 24, 2026

5.0

Dr. Sepe knows how to listen to his patients and actually have a conversation with them.

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February 16, 2026

5.0

He is knowledgeable and provides good care

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February 14, 2026

5.0

Best dr.

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February 13, 2026

5.0

Dr. Sepe has great bedside manners, he makes me feel at ease and kindly answers all my questions. I always feel like I have learned something useful regarding steps I can take to better my health.

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February 13, 2026

5.0

Attentive and kind

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February 11, 2026

5.0

he's a excellent doctor and he's does a great job always. I always have a good experience in the care of dr sepe.

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February 10, 2026

5.0

He cares about his patients and is very efficient

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February 09, 2026

4.0

I wish there was better availability to see a pcp.

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February 02, 2026

5.0

Listening to my concerns and we came up with a plan to address them

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February 01, 2026

5.0

Dr Sepe listens to concerns and has experience and knowledge to care for my health

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January 31, 2026

5.0

He's good!!!

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January 27, 2026

5.0

Very knowledgeable.

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January 15, 2026

5.0

He is very calm and patience when dealing with his patients.

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January 15, 2026

5.0

Dr Sepe listens to what you have to say and is very kind and patient

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January 13, 2026

5.0

He listens and is very detailed. I have referred 2 of my family members to him and one friend. They really like him.

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January 10, 2026

5.0

Dr. Sepe was helpful and understanding of my situation. We have a plan to move forward with his help.

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January 08, 2026

5.0

Dr.Sepe responded to my message and immediately set up an appointment. He explained everything to me and he was very helpful and caring.

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January 07, 2026

5.0

Dr. Sepe is highly collaborative. He provides me with information and guidance that to my assessment is 'best in practice'.

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January 05, 2026

5.0

Same reasons as above. So nice and makes one feel important and examined my concerns. Trust

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December 31, 2025

5.0

Dr. Sepe is an excellent doctor. I thought he was very smart and explained things well. Very personable.

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December 29, 2025

4.0

Very pleasant!, good listener, good recommendation.

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December 25, 2025

5.0

Easy to understand and accommodating.

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December 23, 2025

5.0

HE IS A GREAT DOCTOR AND I FEEL TOTALLY PLEASED THAT HE IS MY PRIMRY CARE DOCTOR AND I WOULD NOT TRADE HIM FOR ANYONE ELSE!!!!!!!!!!!!!!!!!

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December 23, 2025

5.0

Excellent physician

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December 22, 2025

5.0

Kind, attentive and professional.

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December 21, 2025

5.0

He's a great Dr

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December 19, 2025

5.0

Thorough, knowledgeable, patient, and answers all questions.

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December 18, 2025

5.0

He's a good Doctor.

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December 18, 2025

5.0

He is a kind, attentive professional.

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December 17, 2025

5.0

He's great.

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December 15, 2025

5.0

Dr Sepe gave some real advice on my health care

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December 15, 2025

5.0

Took time to explain issues and answer quey

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December 11, 2025

5.0

Dr. Sepe is respectful, knowledgeable, skillful, and easyvto talk with.

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December 11, 2025

5.0

Dr. Daniel J Sepe and his team provide care and treatment in a manner that engenders trust. I always feel that I am in the finest medical center with skilled competent and caring professionals. I continue my great health, with gratitude. Kindest regards

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December 10, 2025

5.0

He seems very competent and caring.

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December 10, 2025

5.0

Attentive, caring, professional

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December 08, 2025

5.0

Knowledgeable and cares

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December 08, 2025

5.0

Dr Sepe is everything anyone could hope for in a doctor. I would and do highly recommend him and Northwestern Medicine.

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December 07, 2025

5.0

Dr Sepe is excellent doctor. He asks and listens to patient concerns and address any and all questions accordingly. He advises of options and gives his medical opinion but allows you to advocate for yourself if you happen to disagree

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December 05, 2025

5.0

Young doctor seems to be knowledgeable. Would like to have my son visit him for a checkup.

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December 04, 2025

5.0

Dr. Sepe is very patient focused. Takes time to answer all questions.

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December 03, 2025

5.0

Dr. Sepe is extremely thorough and I trust his judgement to provide for my care.

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December 01, 2025

5.0

He seems caring, asks good questions, listens thoroughly to answer and asks good follow up questions.

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December 01, 2025

5.0

He is awesome! Glad I found him. Recommended 2 family members and a co-worker see him. They did and are very happy they did. He Listens. Does not rush you! Very detailed. Nice person

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November 27, 2025

5.0

Dr. Sepe is a wonderful Doctor. I would definitely recommend him.

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November 26, 2025

5.0

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November 25, 2025

5.0

Knowledgeable, listens and explains things thoroughly.

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November 25, 2025

5.0

Dr. Daniel Sepe was very thorough and patient. He also talked about all of my concerns.

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November 21, 2025

5.0

Very caring very professional great service

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November 17, 2025

5.0

thorough and friendly

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November 12, 2025

5.0

professipnal thorough

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November 09, 2025

5.0

Dr. Sepe listened and heard to my concerns. Provide very good advice. Did not feel rushed.

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November 05, 2025

5.0

I feel comfortable when talking to him about medical issues

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November 04, 2025

5.0

Dr. Sepe is very attentive, caring and knowledgeable.

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November 04, 2025

5.0

I like him very much, great doctor

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November 02, 2025

5.0

It is pleasure seeing Dr. Sepe for my annual checkups. He is also prompt with test results.

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November 02, 2025

5.0

He's timely, professional, concise, direct, approachable and kind.

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November 01, 2025

5.0

He is great.

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October 31, 2025

5.0

Fast, smart, knowledgable, no nonsense.

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October 28, 2025

5.0

He has the patience for patience. Listens to what I have to say.

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October 28, 2025

5.0

Very knowledgeable, courteous and thorough.

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October 25, 2025

5.0

He listened to my concerns and addressed them.

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October 24, 2025

5.0

Very thorough and willing to refer me to specialists.

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October 24, 2025

4.0

He is a good Doctor

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October 23, 2025

5.0

Provides highest level of attention and support to addressing my health needs. Very trustworthy caregiver.

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October 23, 2025

5.0

Very pleasant and thorough with my visit.

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October 21, 2025

5.0

Dr. Sepe listened carefully and provided enough time and the explanation of his advice and the interaction and side effects of the current and additional medications was very helpful. I was also grateful for the follow up appointment to check on the results of the changes.

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October 21, 2025

5.0

He really listens and cares.

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October 17, 2025

4.0

He seems to really care.

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October 17, 2025

5.0

He's thorough

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October 08, 2025

5.0

thorough exam, answered my questions, nice to speak with.

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October 08, 2025

5.0

Because my Dr. is the best doctor I ever had

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October 07, 2025

5.0

He is very professional and attentive to all my questions and concerns.

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October 03, 2025

5.0

Very thorough

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October 01, 2025

5.0

Answers my medical questions very well.

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September 30, 2025

5.0

He is thorough and follows through.

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September 30, 2025

5.0

Thorough.

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September 29, 2025

5.0

Dr Sepe is a very nice physician and I felt understood and heard.

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September 25, 2025

5.0

Dr. Sepe is very thorough in all phases of care be it the physical examination itself, interviewing/questioning, explaining circumstances, conditions, cause and effects, treatments etc. He dots all of the Is and crosses all of the Ts, always with a very pleasant and approachable demeanor. I'm very happy and feel very fortunate to have him as my new PCP.

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September 15, 2025

5.0

Dr. Sepe is a very nice person.

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September 15, 2025

5.0

I feel others would want the same type of experience when seeing a doctor

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September 14, 2025

5.0

Good doctor

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September 13, 2025

5.0

Dr. Sepe is attentive to my health, my questions and fully explains his recommendations on my care, without dumbing down the explanations.

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September 12, 2025

5.0

He is very knowledgable and good manner.

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September 11, 2025

5.0

Dr. Sepe keeps track of my health and keeps me informed. He makes appropriate referrals when necessary (most recently to the excellent Dr, [last name], orthopedics).

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September 08, 2025

5.0

Knowledgeable, caring, listens and explains

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August 27, 2025

5.0

Very Thoughtful & Thorough. Extremely Helpful. Cares About His Patients.

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August 26, 2025

5.0

I would have no problems recommending Dr. Sepe. I have already recommended someone to him.

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August 21, 2025

5.0

Excellent and caring physician who gives good medical advice.

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August 18, 2025

5.0

He is willing to take the time to discuss all of your issues and offers knowledgable incites into each issue and how to address it.

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August 18, 2025

5.0

Very thorough

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August 14, 2025

5.0

Dr. Sepe was thorough, efficient and compassionate.

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August 14, 2025

5.0

he takes time with me and answers all my questions thoroughly

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August 12, 2025

5.0

Dr [ ] replacement and Dr Sepe is a very thorough Dr for me and my family it's been a very smooth transition.

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August 06, 2025

5.0

Professional and caring

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Disclosures

Daniel J. Sepe, MD reported no external professional relationships for calendar year 2024.

External Professional Relationships

Pharmaceutical, device, and biotechnology companies frequently collaborate with basic scientists and physicians within an academic medical center to help advance science and improve patient care. These relationships are important in achieving scientific breakthroughs and in establishing the effectiveness and safety of promising new therapies. In order to assure objectivity in clinical research and patient care, the Northwestern University Feinberg School of Medicine (Feinberg), Northwestern Memorial HealthCare, Children's Hospital of Chicago Medical Center, and the Shirley Ryan AbilityLab have adopted integrity policies that require research and clinical faculty (in full-time, part-time, and unpaid/voluntary categories) to report compensated and uncompensated external industry relationships. Patients are encouraged to discuss these disclosures with their physician as well as to inquire as to how these relationships are overseen by Feinberg. To learn more about our Disclosure and Professional Integrity Policy, and the conflict of interest policies of our joint affiliate survey partners, please go to our Office for Regulatory Affairs Policies page.

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