The Northwestern Medicine Gender Pathways Program provides high quality, affirming health care to transgender and non-binary people through the consideration of a person's holistic experience of their gender across the lifespan. We utilize a model of integrated health services to bring together a multidisciplinary team that addresses aspects of a person's medical, emotional, social, and legal transition. In addition, the Gender Pathways Program promotes education, research, and advocacy to advance the progress of gender affirming care.