Causes and Diagnoses

Causes and Diagnoses of Scleroderma

Scleroderma is believed to be an autoimmune disease, a condition that—in this case—causes the immune system to produce too much collagen (the protein that makes up the body's connective tissues, including the skin). The cause of scleroderma or what triggers the overproduction and accumulation of collagen is unknown. 


Scleroderma is usually diagnosed based on medical history, a physical examination and notable changes in the skin or internal organs. In addition, an antibody test may help distinguish the type of scleroderma.